方法对比
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| 剂量-反应实验设计与分析× | 重复测量方差分析× | |
|---|---|---|
| 领域≠ | 实验设计 | 统计学 |
| 方法族 | Hypothesis test | Hypothesis test |
| 起源年份≠ | 1994 | 1992 |
| 提出者≠ | Classical pharmacology; formalized by ICH E4 (1994) and Ritz et al. (2015) | Girden (textbook treatment); Field (2013) |
| 类型≠ | Nonlinear curve fitting and monotone contrast testing | Parametric within-subjects mean comparison |
| 开创性文献≠ | Ritz, C., Baty, F., Streibig, J. C., & Gerhard, D. (2015). Dose-Response Analysis Using R. PLOS ONE, 10(12), e0146021. DOI ↗ | Field, A. (2013). Discovering Statistics Using IBM SPSS Statistics (4th ed., Ch. 14). SAGE. ISBN: 978-1446249185 |
| 别名≠ | dose-response analysis, dose-response curve, Doz-Yanıt Tasarımı ve Analizi (Dose-Response), ED50 analysis | within-subjects ANOVA, repeated measures analysis of variance, rm-ANOVA, Tekrarlı Ölçüm ANOVA |
| 相关 | 4 | 4 |
| 摘要≠ | Dose-response design is a framework for planning and analysing experiments that characterise the relationship between the amount of a stimulus — such as a drug dose or a chemical concentration — and the magnitude of a biological or physiological response. Formalised in regulatory guidance by the ICH E4 guideline (1994) and extensively developed in the statistical literature by Ritz et al. (2015), the framework covers experiment design, four-parameter and five-parameter logistic curve fitting, key benchmark estimates (ED50/EC50, NOAEL, LOAEL), and monotone trend testing via the Williams procedure. | Repeated-measures ANOVA is a parametric hypothesis test that compares three or more measurements taken from the same individuals — typically across time points or conditions — to decide whether their means differ. It extends one-way ANOVA to within-subjects designs, as treated in standard references such as Girden (1992) and Field (2013). |
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