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| 剂量-反应实验设计与分析× | 药代动力学房室模型× | |
|---|---|---|
| 领域≠ | 实验设计 | 定量药理学 |
| 方法族≠ | Hypothesis test | Regression model |
| 起源年份≠ | 1994 | 1982 |
| 提出者≠ | Classical pharmacology; formalized by ICH E4 (1994) and Ritz et al. (2015) | Gibaldi & Perrier |
| 类型≠ | Nonlinear curve fitting and monotone contrast testing | Deterministic ODE-based pharmacokinetic model |
| 开创性文献≠ | Ritz, C., Baty, F., Streibig, J. C., & Gerhard, D. (2015). Dose-Response Analysis Using R. PLOS ONE, 10(12), e0146021. DOI ↗ | Gibaldi, M., & Perrier, D. (1982). Pharmacokinetics (2nd ed.). Marcel Dekker. ISBN: 978-0-8247-1042-2 |
| 别名≠ | dose-response analysis, dose-response curve, Doz-Yanıt Tasarımı ve Analizi (Dose-Response), ED50 analysis | Mammillary Compartment Model, Multi-Compartment PK Model, Compartmental Analysis, Farmakokinetik Kompartman Modeli |
| 相关≠ | 4 | 3 |
| 摘要≠ | Dose-response design is a framework for planning and analysing experiments that characterise the relationship between the amount of a stimulus — such as a drug dose or a chemical concentration — and the magnitude of a biological or physiological response. Formalised in regulatory guidance by the ICH E4 guideline (1994) and extensively developed in the statistical literature by Ritz et al. (2015), the framework covers experiment design, four-parameter and five-parameter logistic curve fitting, key benchmark estimates (ED50/EC50, NOAEL, LOAEL), and monotone trend testing via the Williams procedure. | The pharmacokinetic compartment model represents the body as one or more hypothetical compartments interconnected by first-order rate processes, describing how a drug is absorbed, distributed, and eliminated over time. Systematized by Gibaldi and Perrier in 1982, these models use ordinary differential equations to characterize plasma concentration-time profiles. They are the cornerstone of drug development, dosage regimen design, and regulatory submission pharmacokinetic analyses. |
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