方法对比

	簇随机化的所罗门四组设计	析因随机对照试验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	1949 (Solomon design); cluster extension formalized in 1990s	1926 (Fisher factorial foundations); 2000s–2010s (clinical factorial RCT formalization)
提出者	Richard L. Solomon (four-group logic, 1949); cluster randomization methods developed by Murray and colleagues in the 1990s	R. A. Fisher (factorial design foundations); adapted into clinical trials via MOST framework (Collins et al., 2014)
类型	Experimental design	Experimental trial design
开创性文献	Solomon, R. L. (1949). An extension of control group design. Psychological Bulletin, 46(2), 137–150.	Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498–504.
别名	CR-S4GD, cluster-randomized four-group design, group-randomized Solomon design, Solomon four-group cluster trial	Factorial RCT, factorial trial, multi-factor RCT, factorial experiment with randomization
相关	6	6
摘要	The cluster randomized Solomon four-group design combines cluster randomization — assigning intact groups such as schools, clinics, or communities to conditions — with the Solomon four-group structure that isolates the effect of pretesting. Four clusters (or sets of clusters) are created: two receive the treatment and two serve as controls, with only one treatment cluster and one control cluster receiving a pretest, while the others go straight to the posttest. This structure simultaneously controls for pretest sensitization and the logistical constraint that individual randomization is infeasible.	A factorial randomized controlled trial (factorial RCT) is an experimental design in which participants are randomly assigned to every possible combination of two or more independent factors (treatments or intervention components) simultaneously. This allows researchers to estimate the main effect of each factor and their interactions within a single, efficient trial, rather than running separate experiments for each factor.