方法对比

	簇随机适应性试验	分块随机对照试验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	2000s–2010s	1920s (Fisher's blocking principle); applied to RCTs from the 1940s onward
提出者	Synthesised from cluster randomization methodology (Donner, 1978; Donner & Klar, 2000) and adaptive design frameworks (Bauer & Kohne, 1994; Pallmann et al., 2018)	R. A. Fisher (blocking principle); systematic RCT application by Bradford Hill and later Pocock, Friedman et al.
类型	Experimental design	Experimental design
开创性文献	Hayes, R. J., & Moulton, L. H. (2017). Cluster Randomised Trials (2nd ed.). CRC Press / Chapman & Hall. ISBN: 978-1498728225	Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915856
别名	adaptive cluster RCT, adaptive group-randomized trial, cluster adaptive design, adaptive cluster trial	blocked RCT, block-randomized trial, stratified block randomization trial, permuted block randomization
相关	5	5
摘要	A cluster randomized adaptive experiment combines two methodological principles: (1) intact groups such as schools, clinics, or villages are randomly assigned to treatment conditions rather than individuals, and (2) pre-specified rules allow the design to be modified during the trial based on accumulating cluster-level data. Adaptations may include dropping underperforming arms, reallocating clusters, or adjusting sample size, while maintaining statistical validity and controlling Type I error.	A blocked randomized controlled trial (blocked RCT) uses permuted-block randomization to ensure that treatment groups remain balanced in size — and optionally in key characteristics — throughout recruitment. Within each block of fixed or randomly varied size, all treatment allocations are present in equal numbers, so imbalance cannot accumulate even if the trial is stopped early. This makes blocked RCTs the standard randomization approach in clinical and behavioral intervention research.