方法对比

	Ancient DNA Analysis	Paleodemographic Analysis
领域	考古学	考古学
方法族	Process / pipeline	Process / pipeline
起源年份	2004	1982
提出者	Svante Paabo and colleagues (foundational methodology)	Jean-Pierre Bocquet-Appel & Claude Masset (critique); Rostock School (hazard-model solution)
类型	Laboratory and computational pipeline for recovering and authenticating genetic data from archaeological remains	Inferential pipeline for estimating mortality, fertility, and age structure from skeletal age-at-death distributions
开创性文献	Paabo, S., et al. (2004). Genetic Analyses from Ancient DNA. Annual Review of Genetics, 38, 645-679.	Bocquet-Appel, J.-P., & Masset, C. (1982). Farewell to Paleodemography. Journal of Human Evolution, 11(4), 321-333.
别名	aDNA Analysis, Archaeogenetics, Ancient Genomics, Palaeogenetics	Paleodemography, Skeletal Demography, Past Population Mortality Analysis, Osteological Demography
相关	2	2
摘要	Ancient DNA analysis recovers genetic information from the degraded remains of past organisms — human and animal bones and teeth, and increasingly sediments — and uses it to reconstruct kinship, ancestry, population history, sex, pathogens, and domestication. Because DNA fragments into ever-shorter pieces and accumulates characteristic chemical damage after death, and because a handful of modern molecules can swamp the few authentic ones, the field is defined less by sequencing itself than by an exacting protocol of clean-lab extraction, contamination control, and authentication. The foundational reviews by Svante Paabo and colleagues set out the principles that distinguish genuine ancient sequences from contaminants, and the move to next-generation sequencing transformed aDNA from a fragile curiosity into a routine source of genome-scale data.	Paleodemographic analysis reconstructs the demographic life of past populations — their mortality schedules, life expectancy, age structure, and fertility — from the age-at-death distributions of skeletal samples. It begins from the per-individual ages produced by osteological estimation and aggregates them into life tables or, increasingly, fits formal mortality models. The field was reshaped by Bocquet-Appel and Masset's bracing 1982 critique, 'Farewell to Paleodemography,' which exposed two fatal biases: the tendency of skeletal age estimates to mimic the age structure of the reference sample rather than the target population, and the corrupting effect of age-estimation error. The modern response, developed by the Rostock School and others, abandons naive life tables in favor of hazard models and Bayesian estimation that treat the observed data as the noisy product of a true mortality schedule.