方法对比
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| 异速生长药代动力学标度× | 群体药效学模型× | |
|---|---|---|
| 领域 | 药理学 | 药理学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1989 | 1992 |
| 提出者≠ | John Mordenti | Lewis Sheiner and Stephen Roush |
| 类型≠ | inter-species extrapolation | dose-response modeling |
| 开创性文献≠ | Mordenti, J., & Chappell, W. (1989). The use of allometric scaling in toxicokinetic studies. Fundamental and Applied Toxicology, 13(2), 335-346. link ↗ | Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57. link ↗ |
| 别名 | allometric scaling, inter-species extrapolation, FIH dose prediction | PopPD, population PD, hierarchical PD modeling |
| 相关 | 3 | 3 |
| 摘要≠ | Allometric scaling is a mathematical approach for predicting human pharmacokinetics from preclinical animal data using body weight relationships. Developed systematically by Mordenti and colleagues in the late 1980s, it enables rational first-in-human dose prediction without assuming species-specific metabolic differences. | Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction. |
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