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| 异速生长药代动力学标度× | 米氏动力学× | |
|---|---|---|
| 领域 | 药理学 | 药理学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1989 | 1913 |
| 提出者≠ | John Mordenti | Leonor Michaelis and Maud Menten |
| 类型≠ | inter-species extrapolation | mechanistic model |
| 开创性文献≠ | Mordenti, J., & Chappell, W. (1989). The use of allometric scaling in toxicokinetic studies. Fundamental and Applied Toxicology, 13(2), 335-346. link ↗ | Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369. link ↗ |
| 别名 | allometric scaling, inter-species extrapolation, FIH dose prediction | MM kinetics, Michaelis constant, Vmax |
| 相关≠ | 3 | 2 |
| 摘要≠ | Allometric scaling is a mathematical approach for predicting human pharmacokinetics from preclinical animal data using body weight relationships. Developed systematically by Mordenti and colleagues in the late 1980s, it enables rational first-in-human dose prediction without assuming species-specific metabolic differences. | Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics. |
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