方法对比

	自适应全因子实验	析因随机对照试验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	1950s (factorial foundations); adaptive extensions prominent from 1990s onward	1926 (Fisher factorial foundations); 2000s–2010s (clinical factorial RCT formalization)
提出者	Rooted in Box & Hunter factorial design tradition; adaptive extensions formalised by Atkinson, Donev and others in optimal design theory	R. A. Fisher (factorial design foundations); adapted into clinical trials via MOST framework (Collins et al., 2014)
类型	Experimental design	Experimental trial design
开创性文献	Atkinson, A., Donev, A., & Tobias, R. (2007). Optimum Experimental Designs, with SAS. Oxford University Press. ISBN: 978-0199296606	Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498–504.
别名	adaptive full-factorial design, sequential full factorial experiment, adaptive complete factorial design, dynamic full factorial trial	Factorial RCT, factorial trial, multi-factor RCT, factorial experiment with randomization
相关	5	6
摘要	An adaptive full factorial experiment is an experimental design that starts with a complete crossing of all factors and all their levels, then uses interim data to modify subsequent runs — dropping unpromising factor levels, adding new ones, or re-allocating replication — while preserving the full factorial structure within each phase. This integration of full factorial coverage with adaptive decision rules allows researchers to explore all main effects and interactions without committing to a fixed, inefficient run plan before any data are observed.	A factorial randomized controlled trial (factorial RCT) is an experimental design in which participants are randomly assigned to every possible combination of two or more independent factors (treatments or intervention components) simultaneously. This allows researchers to estimate the main effect of each factor and their interactions within a single, efficient trial, rather than running separate experiments for each factor.