方法对比
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| 自适应病例系列× | 自适应队列研究× | |
|---|---|---|
| 领域 | 流行病学 | 流行病学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | Late 20th–early 21st century | 2000s–2010s (systematic formalisation) |
| 提出者≠ | Evolved from classical case series methodology combined with adaptive design principles (Chow & Chang, 2008; FDA adaptive design guidance) | Extension of classic cohort methods; adaptive design principles formalised by regulatory and epidemiology communities in the 2000s–2010s |
| 类型≠ | Observational study with adaptive monitoring | Observational / adaptive epidemiological design |
| 开创性文献≠ | Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887775 | VanderWeele, T. J., & Hernan, M. A. (2012). Results on differential and dependent measurement error of the exposure and the outcome using signed directed acyclic graphs. American Journal of Epidemiology, 175(12), 1303–1310. DOI ↗ |
| 别名≠ | adaptive case-series design, sequential adaptive case series, adaptive observational case series | adaptive longitudinal study, flexible cohort design, adaptive prospective cohort, ACS |
| 相关≠ | 5 | 4 |
| 摘要≠ | An adaptive case series is an observational study design that documents a consecutive group of patients with a shared condition or exposure while incorporating pre-specified rules for modifying data collection, monitoring, or stopping criteria as accumulating evidence warrants. It combines the descriptive richness of traditional case series with the prospective flexibility of adaptive design principles, enabling structured mid-course adjustments without compromising the integrity of the recorded clinical observations. | An adaptive cohort study is a longitudinal observational design that follows a defined group of individuals over time to assess exposure-outcome relationships, while incorporating pre-specified adaptation rules that allow protocol modifications — such as sample-size re-estimation, subgroup enrichment, or measurement schedule adjustments — based on accumulating interim data. Adaptations are made without compromising validity, guided by a statistical analysis plan agreed upon before data collection begins. |
| ScholarGate数据集 ↗ |
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