Process / pipelineGrowth factor delivery
骨形态发生蛋白（BMP）释放测定
骨形态发生蛋白（BMP）释放测定用于测量生物材料载体随时间释放BMP的动力学和量。BMP-2、BMP-6、BMP-7和BMP-9是Marshall Urist于1965年发现的强效骨诱导生长因子，可触发骨和软骨的形成。当BMP加载到支架、水凝胶或植入物中时，必须以受控方式释放，以最大化生物效应并最小化全身暴露。释放测定在设定的时间点量化周围介质中BMP的含量，从而能够针对骨再生和骨折愈合应用优化载体材料和释放曲线。
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来源
- Urist, M. R. (1965). Bone: formation by autoinduction. Science, 150(3698), 893-899. DOI: 10.1126/science.150.3698.893 ↗
- Reddi, A. H. (2001). Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, gremlin, and chordin. Arthritis Research, 3(1), 1-5. link ↗
- Garrison, K. R., Donell, S., Reuben, A., et al. (2010). Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the management of fractures of long bones: a systematic review. The Journal of Bone and Joint Surgery, 89(4), 477-490. link ↗
如何引用本页
ScholarGate. (2026, June 3). Bone Morphogenetic Protein Release Kinetics Assay. ScholarGate. https://scholargate.app/zh/biomaterials/bmp-release
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