So sánh phương pháp

	Thiết kế thí nghiệm tối ưu (Tối ưu D, Tối ưu I)	Thiết kế Lập phương Trung tâm
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Hypothesis test	Process / pipeline
Năm ra đời	1972	1951
Người khởi xướng	V. V. Fedorov	George E. P. Box and K. B. Wilson
Loại	Computer-aided optimal design	Response surface experimental design
Công trình gốc	Fedorov, V.V. (1972). Theory of Optimal Experiments. Academic Press.	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
Tên gọi khác	D-Optimal Design, I-Optimal Design, Computer-Generated Design, Optimal Deneme Deseni (D-Optimal, I-Optimal)	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
Liên quan	5	3
Tóm tắt	Optimal experimental design is a computer-aided approach to constructing experiments that maximises statistical efficiency for a given model and run budget. Formalised by V. V. Fedorov in 1972, it selects experimental points from a candidate set so that the information matrix M = X'X is optimised according to a chosen criterion — most commonly D-optimality (maximising the determinant) or I-optimality (minimising average prediction variance). It is the preferred strategy whenever classical designs such as central composite or Box-Behnken cannot be applied because the experimental region is constrained or factor ranges are irregular.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.