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| Tìm kiếm Hồ sơ HMMER× | Tái tạo cấu trúc bằng kính hiển vi điện tử lạnh× | |
|---|---|---|
| Lĩnh vực | Tin sinh học | Tin sinh học |
| Họ | Process / pipeline | Process / pipeline |
| Năm ra đời≠ | 1994 | 1975 |
| Người khởi xướng≠ | Sean Eddy | Joachim Frank |
| Loại≠ | Probabilistic sequence search pipeline | Image reconstruction pipeline |
| Công trình gốc≠ | Krogh, A., Brown, M., Mian, I. S., Sjölander, K., & Haussler, D. (1994). Hidden Markov models in computational biology: applications to protein modeling. Journal of Molecular Biology, 235(5), 1501-1531. DOI ↗ | Frank, J. (2002). Single-particle imaging of macromolecules by cryo-electron microscopy. Annual Review of Biophysics and Biomolecular Structure, 31, 303-319. DOI ↗ |
| Tên gọi khác | profile-hidden Markov model, HMM profile search, HMMER | cryo-electron microscopy, cryo-EM, single-particle cryo-EM |
| Liên quan | 3 | 3 |
| Tóm tắt≠ | HMMER profile search identifies distant protein sequence homologs using probabilistic models of protein families, known as profile Hidden Markov Models (HMMs). Developed by Eddy and colleagues, this method captures sequence variation patterns within protein families and detects homologs with far greater sensitivity than position-weight matrices or pairwise alignment. | Cryo-electron microscopy (cryo-EM) determines three-dimensional macromolecular structures at atomic or near-atomic resolution by imaging proteins frozen in vitreous ice. Pioneered by Frank, Henderson, and others, this technique has revolutionized structural biology by enabling visualization of large, non-crystallizable complexes and capturing functional conformational states. |
| ScholarGateBộ dữ liệu ↗ |
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