So sánh phương pháp

	Bài kiểm tra HKA	Lý thuyết Coalescent	McDonald-Kreitman Test	Quét chọn lọc (Tajima's D)
Lĩnh vực	Di truyền học	Di truyền học	Di truyền học	Di truyền học
Họ	Process / pipeline	Process / pipeline	Process / pipeline	Process / pipeline
Năm ra đời	1987	1982	1991	1989
Người khởi xướng	Richard Hudson, Martin Kreitman & Montserrat Aguade	John Kingman	James McDonald & Martin Kreitman	Fumio Tajima
Loại	Statistical test	Stochastic process model	Hypothesis test	Neutrality test
Công trình gốc	Hudson, R. R., Kreitman, M., & Aguadé, M. (1987). A test of neutral molecular evolution based on nucleotide data. Genetics, 116(1), 153–159.	Kingman, J. F. C. (1982). The coalescent. Stochastic Processes and their Applications, 13(3), 235–248.	McDonald, J. H., & Kreitman, M. (1991). Adaptive protein evolution at the Adh locus in Drosophila. Nature, 351(6328), 652–654.	Tajima, F. (1989). Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics, 123(3), 585–595.
Tên gọi khác	HKA test, Polymorphism divergence test	Kingman Coalescent, n-coalescent	MK test, Positive selection test	Tajima's D test, Selective sweep analysis, Neutrality test
Liên quan	4	4	4	4
Tóm tắt	The Hudson-Kreitman-Aguade (HKA) test is a statistical method that tests for neutral evolution by comparing levels of within-population polymorphism and between-population divergence at multiple loci. Developed by Hudson, Kreitman, and Aguade in 1987, this test uses the principle that neutral loci should show expected relationships between polymorphism and divergence. Loci deviating from these relationships are candidates for selection. The HKA test is particularly useful for detecting selection in genome-wide surveys because it uses relative comparisons across loci rather than requiring external calibration.	Coalescent theory is a probabilistic framework that traces the genealogical history of DNA sequences backward in time to their most recent common ancestor. Developed by John Kingman in 1982, this method forms the foundation of modern population genetics, enabling researchers to understand demographic events, estimate genetic parameters, and reconstruct evolutionary histories from modern genetic data.	The McDonald-Kreitman (MK) test is a statistical method for detecting adaptive evolution by comparing ratios of synonymous and nonsynonymous substitutions within and between species. Developed by James McDonald and Martin Kreitman in 1991, this test exploits the key insight that neutral mutations accumulate at similar rates within and between species, while adaptive (nonsynonymous) substitutions should be enriched between species if they have been fixed by positive selection. The MK test has become a standard tool in molecular evolutionary biology for identifying genes under natural selection.	Tajima's D is a statistical test designed to detect selective sweeps—recent, rapid fixation of advantageous mutations—from patterns of genetic variation in DNA sequences. Developed by Fumio Tajima in 1989, this test measures deviations from neutrality by comparing different measures of DNA sequence diversity. A significant Tajima's D value indicates departure from neutral evolution, suggesting positive selection, population structure, or demographic events.