So sánh phương pháp
Xem các phương pháp đã chọn cạnh nhau; những hàng khác biệt được làm nổi bật.
| Thiết kế và Phân tích Thử nghiệm Đáp ứng Liều× | Phân tích phương sai đo lặp (Repeated-measures ANOVA)× | |
|---|---|---|
| Lĩnh vực≠ | Thiết kế thí nghiệm | Thống kê |
| Họ | Hypothesis test | Hypothesis test |
| Năm ra đời≠ | 1994 | 1992 |
| Người khởi xướng≠ | Classical pharmacology; formalized by ICH E4 (1994) and Ritz et al. (2015) | Girden (textbook treatment); Field (2013) |
| Loại≠ | Nonlinear curve fitting and monotone contrast testing | Parametric within-subjects mean comparison |
| Công trình gốc≠ | Ritz, C., Baty, F., Streibig, J. C., & Gerhard, D. (2015). Dose-Response Analysis Using R. PLOS ONE, 10(12), e0146021. DOI ↗ | Field, A. (2013). Discovering Statistics Using IBM SPSS Statistics (4th ed., Ch. 14). SAGE. ISBN: 978-1446249185 |
| Tên gọi khác≠ | dose-response analysis, dose-response curve, Doz-Yanıt Tasarımı ve Analizi (Dose-Response), ED50 analysis | within-subjects ANOVA, repeated measures analysis of variance, rm-ANOVA, Tekrarlı Ölçüm ANOVA |
| Liên quan | 4 | 4 |
| Tóm tắt≠ | Dose-response design is a framework for planning and analysing experiments that characterise the relationship between the amount of a stimulus — such as a drug dose or a chemical concentration — and the magnitude of a biological or physiological response. Formalised in regulatory guidance by the ICH E4 guideline (1994) and extensively developed in the statistical literature by Ritz et al. (2015), the framework covers experiment design, four-parameter and five-parameter logistic curve fitting, key benchmark estimates (ED50/EC50, NOAEL, LOAEL), and monotone trend testing via the Williams procedure. | Repeated-measures ANOVA is a parametric hypothesis test that compares three or more measurements taken from the same individuals — typically across time points or conditions — to decide whether their means differ. It extends one-way ANOVA to within-subjects designs, as treated in standard references such as Girden (1992) and Field (2013). |
| ScholarGateBộ dữ liệu ↗ |
|
|