เปรียบเทียบวิธี

	การติดตามระดับยาในเลือด (Therapeutic Drug Monitoring - TDM)	แบบจำลองเชิงปริมาตรเภสัชจลนศาสตร์
สาขาวิชา	เภสัชมิติ	เภสัชมิติ
ตระกูล	Regression model	Regression model
ปีกำเนิด	1988	1982
ผู้ริเริ่ม	Reynold Spector et al.	Gibaldi & Perrier
ประเภท	Clinical measurement and dose-optimization framework	Deterministic ODE-based pharmacokinetic model
แหล่งต้นตำรับ	Spector, R., Park, G. D., Johnson, G. F., & Vesell, E. S. (1988). Therapeutic drug monitoring. Clinical Pharmacology & Therapeutics, 43(4), 345–353.	Gibaldi, M., & Perrier, D. (1982). Pharmacokinetics (2nd ed.). Marcel Dekker. ISBN: 978-0-8247-1042-2
ชื่อเรียกอื่น	Drug Level Monitoring, Serum Drug Level Monitoring, Clinical Pharmacokinetic Monitoring, İlaç Düzeyi İzlemi	Mammillary Compartment Model, Multi-Compartment PK Model, Compartmental Analysis, Farmakokinetik Kompartman Modeli
ที่เกี่ยวข้อง	3	3
สรุป	Therapeutic Drug Monitoring (TDM) is a clinical pharmacokinetic practice in which drug concentrations are measured in a patient's blood to guide individualized dosing. It applies principally to drugs with narrow therapeutic windows—where the margin between efficacy and toxicity is small—such as aminoglycosides, vancomycin, cyclosporine, and antiepileptics. Developed as a formal discipline in the 1980s, TDM integrates measured concentrations with pharmacokinetic modeling to calculate patient-specific dose regimens.	The pharmacokinetic compartment model represents the body as one or more hypothetical compartments interconnected by first-order rate processes, describing how a drug is absorbed, distributed, and eliminated over time. Systematized by Gibaldi and Perrier in 1982, these models use ordinary differential equations to characterize plasma concentration-time profiles. They are the cornerstone of drug development, dosage regimen design, and regulatory submission pharmacokinetic analyses.