เปรียบเทียบวิธี

	การทดลองสุ่มและมีกลุ่มควบคุมแบบปกปิดฝ่ายเดียว	การทดลองสุ่มและมีกลุ่มควบคุม (Randomized Controlled Trial - RCT)
สาขาวิชา	การออกแบบการทดลอง	การออกแบบการทดลอง
ตระกูล	Process / pipeline	Hypothesis test
ปีกำเนิด	1948 (formalized); single-blind variant established in mid-20th century clinical trial methodology	1948
ผู้ริเริ่ม	Bradford Hill and colleagues (MRC streptomycin trial, 1948); blinding conventions codified in CONSORT guidelines	James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948)
ประเภท	Experimental design — blinded randomized trial	Interventional comparative study
แหล่งต้นตำรับ	Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332.	Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332.
ชื่อเรียกอื่น	single-masked RCT, single-blind RCT, single-blind trial, SB-RCT	RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı
ที่เกี่ยวข้อง	5	7
สรุป	A single-blind randomized controlled trial (SB-RCT) is a rigorous experimental design in which participants are randomly assigned to treatment or control conditions while remaining unaware of which condition they have received. Investigators, outcome assessors, and data analysts are not blinded. By masking participants, the design eliminates placebo and nocebo response biases on the participant side, while preserving investigator flexibility to administer and monitor the intervention.	A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010).