เปรียบเทียบวิธี

	การทดลองสุ่มและมีกลุ่มควบคุมแบบปกปิดฝ่ายเดียว	การทดลองแบบสุ่มและมีกลุ่มควบคุมแบบกลุ่ม
สาขาวิชา	การออกแบบการทดลอง	การออกแบบการทดลอง
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	1948 (formalized); single-blind variant established in mid-20th century clinical trial methodology	1978–1980s
ผู้ริเริ่ม	Bradford Hill and colleagues (MRC streptomycin trial, 1948); blinding conventions codified in CONSORT guidelines	Cornfield (1978); systematised by Donner and colleagues (1980s)
ประเภท	Experimental design — blinded randomized trial	Experimental design
แหล่งต้นตำรับ	Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332.	Donner, A., & Klar, N. (2000). Design and Analysis of Cluster Randomization Trials in Health Research. Arnold. ISBN: 978-0340652978
ชื่อเรียกอื่น	single-masked RCT, single-blind RCT, single-blind trial, SB-RCT	cluster RCT, group-randomized trial, community randomized trial, cluster-randomized experiment
ที่เกี่ยวข้อง	5	4
สรุป	A single-blind randomized controlled trial (SB-RCT) is a rigorous experimental design in which participants are randomly assigned to treatment or control conditions while remaining unaware of which condition they have received. Investigators, outcome assessors, and data analysts are not blinded. By masking participants, the design eliminates placebo and nocebo response biases on the participant side, while preserving investigator flexibility to administer and monitor the intervention.	A cluster randomized controlled trial (cluster RCT) is an experimental design in which intact social or organisational groups — such as schools, clinics, villages, or workplaces — are randomly assigned to treatment conditions rather than individual participants. Outcomes are still measured at the individual level, but the unit of randomization is the cluster. This design is essential when an intervention is delivered to whole groups, when there is a risk of contamination between participants in the same setting, or when individual randomization is logistically or ethically impractical.