เปรียบเทียบวิธี

	การศึกษาแบบกรณี-กลุ่มควบคุมซ้อนหลัง (Retrospective Nested Case-Control Study)	Retrospective case-control study
สาขาวิชา	ระบาดวิทยา	ระบาดวิทยา
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	1973 (formal description); widely adopted in epidemiology from 1980s onward	1950s–1960s (formal methodology)
ผู้ริเริ่ม	Nested case-control formalized by Mantel (1973); retrospective application via historical cohort records	Jerome Cornfield; formalized by Brian MacMahon and others in mid-20th-century epidemiology
ประเภท	Observational analytic study design	Observational analytical study
แหล่งต้นตำรับ	Mantel, N. (1973). Synthetic retrospective studies and related topics. Biometrics, 29(3), 479–486.	Schlesselman, J. J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195029338
ชื่อเรียกอื่น	retrospective NCC, nested case-control within retrospective cohort, case-control nested in historical cohort, nested CCR	case-control study, retrospective case-referent study, case-referent design, trohoc study
ที่เกี่ยวข้อง	5	5
สรุป	A retrospective nested case-control study is an efficient observational design in which cases and matched controls are sampled from within an already-assembled retrospective cohort. Exposure data are retrieved from historical records only for selected participants, dramatically reducing data-collection costs while retaining most of the analytic power of the full cohort. It is widely used in pharmacoepidemiology, occupational health, and disease-registry research.	A retrospective case-control study identifies individuals who already have an outcome of interest (cases) and a comparable group without it (controls), then looks backward in time using existing records to determine prior exposure to a suspected risk factor. The primary measure of association is the odds ratio. This design is especially efficient for studying rare diseases or outcomes with long latency periods, since the outcome has already occurred before the study begins.