เปรียบเทียบวิธี

	การศึกษากรณี-กลุ่มควบคุมเชิงปฏิบัติ	การศึกษาแบบจับคู่กรณี-ควบคุม
สาขาวิชา	ระบาดวิทยา	ระบาดวิทยา
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	1950s–1960s (classical); pragmatic framing 1967–2000s	1950s–1970s
ผู้ริเริ่ม	Evolved from classical case-control methodology (Dorn, 1954; Cornfield, 1956); pragmatic framing formalized by Schwartz & Lellouch (1967)	Brian MacMahon and others; systematised by Schlesselman (1982)
ประเภท	Observational epidemiological study design	Observational analytic design
แหล่งต้นตำรับ	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755474
ชื่อเรียกอื่น	real-world case-control study, pragmatic case-control design, effectiveness case-control study, PCCS	matched case-referent study, individually matched case-control, pair-matched case-control, matched case-control design
ที่เกี่ยวข้อง	6	5
สรุป	A pragmatic case-control study is an observational design that compares individuals who have developed a disease or outcome (cases) with those who have not (controls), using data collected under routine real-world conditions rather than strictly controlled experimental settings. Exposure histories are reconstructed from clinical records, registries, or administrative databases. The design is chosen when a conventional explanatory case-control study would be impractical, unethical, or too narrow to inform actual clinical or public-health decisions.	A matched case-control study is an observational epidemiological design in which each case (a person with the disease or outcome of interest) is paired with one or more controls (persons without the outcome) who share one or more characteristics — such as age, sex, or clinical setting — to control confounding. Exposure history is then compared between cases and their matched controls to estimate the odds ratio of the exposure-disease association.