เปรียบเทียบวิธี

	การวิเคราะห์กลุ่มดีเอ็นเอ (LD Block Analysis)	QTL Mapping
สาขาวิชา	พันธุศาสตร์	พันธุศาสตร์
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	2002	1989
ผู้ริเริ่ม	Shaun Gabriel & Eric Lander	Eric Lander & David Botstein
ประเภท	Haplotype analysis method	Genetic linkage method
แหล่งต้นตำรับ	Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., & Lander, E. S. (2002). The structure of haplotype blocks in the human genome. Science, 296(5576), 2225–2229.	Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199.
ชื่อเรียกอื่น	Haplotype block analysis, LD mapping, Block structure analysis	QTL analysis, Linkage mapping, Trait locus mapping
ที่เกี่ยวข้อง	5	4
สรุป	Linkage disequilibrium (LD) block analysis is a genomic method that partitions the human genome into distinct haplotype blocks—regions of limited recombination where variants are in strong statistical association. First systematically described by Gabriel and colleagues in 2002, this approach reveals the underlying structure of genetic variation and enables efficient genomic studies by reducing the number of variants needed to capture common diversity. LD block analysis forms the foundation of genome-wide association study (GWAS) design and modern population genetics.	Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.