เปรียบเทียบวิธี

	การสร้างแบบจำลองโฮโมโลยี	แบบจำลองฟาร์มาโคฟอร์	โครงสร้างเครือข่ายปฏิสัมพันธ์ระหว่างโปรตีน
สาขาวิชา	ชีวสารสนเทศศาสตร์	ชีวสารสนเทศศาสตร์	ชีวสารสนเทศศาสตร์
ตระกูล	Process / pipeline	Process / pipeline	Process / pipeline
ปีกำเนิด	1993	1977	2000
ผู้ริเริ่ม	Andrej Sali	Peter Gund	Peter Uetz
ประเภท	Comparative structure prediction pipeline	Pattern-based virtual screening pipeline	Network analysis pipeline
แหล่งต้นตำรับ	Sali, A. & Blundell, T. L. (1993). Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology, 234(3), 779-815.	Wermuth, C. G., Ganellin, C. R., Lindberg, P., & Mitscher, L. A. (1998). Glossary of terms used in medicinal chemistry. Pure and Applied Chemistry, 70(5), 1129-1143.	Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., ... & Lomax, J. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403(6770), 623-627.
ชื่อเรียกอื่น	comparative modeling, template-based modeling	pharmacophore pattern recognition, 3D pharmacophore	protein interaction networks, interactome analysis, network topology
ที่เกี่ยวข้อง	4	3	3
สรุป	Homology modeling, also called comparative modeling, predicts the three-dimensional structure of a protein using an experimentally-solved structure of a homologous protein as a template. Introduced by Sali and Blundell in 1993, this method exploits the principle that homologous proteins share similar spatial structures despite differing in amino acid sequence.	Pharmacophore modeling identifies the spatial arrangement of molecular features (hydrogen bond donors, acceptors, aromatic rings) that are essential for biological activity. Introduced by Gund in 1977, this ligand-based method creates a three-dimensional pattern that can screen chemical libraries and design new active compounds without requiring receptor structure.	Protein-protein interaction network analysis identifies and characterizes the structural properties of cellular interaction networks. Pioneered by Uetz and colleagues through large-scale yeast two-hybrid screening, this approach reveals topological features like hubs, modules, and motifs that encode functional organization and disease associations.