เปรียบเทียบวิธี
ดูวิธีที่เลือกเทียบกันแบบเคียงข้าง แถวที่ต่างกันจะถูกเน้นไว้
| การทดลองแบบปกปิดสองทางและการปรับเปลี่ยนได้× | การทดลองสุ่มและมีกลุ่มควบคุม (Randomized Controlled Trial - RCT)× | |
|---|---|---|
| สาขาวิชา | การออกแบบการทดลอง | การออกแบบการทดลอง |
| ตระกูล≠ | Process / pipeline | Hypothesis test |
| ปีกำเนิด≠ | Conceptual roots 1970s–1990s; regulatory codification 2004–2019 | 1948 |
| ผู้ริเริ่ม≠ | Formalized through FDA adaptive design guidance and work by Scott Berry, Donald Berry, and colleagues | James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948) |
| ประเภท≠ | Experimental design combining blinding and adaptive modification | Interventional comparative study |
| แหล่งต้นตำรับ≠ | U.S. Food and Drug Administration. (2019). Adaptive Designs for Clinical Trials of Drugs and Biologics: Guidance for Industry. FDA. link ↗ | Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332. DOI ↗ |
| ชื่อเรียกอื่น | double-blind adaptive design, blinded adaptive trial, double-blind adaptive RCT, adaptive double-blind study | RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı |
| ที่เกี่ยวข้อง≠ | 4 | 7 |
| สรุป≠ | A double-blind adaptive experiment combines two powerful design features: double-blinding, which conceals treatment assignment from both participants and outcome assessors to prevent bias, and adaptive modification, which allows pre-specified changes to the trial's course — such as sample size re-estimation, allocation ratio shifts, or arm dropping — based on accumulating interim data. The result is a rigorous, bias-protected design that can respond to emerging evidence without compromising inferential validity. | A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010). |
| ScholarGateชุดข้อมูล ↗ |
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