เปรียบเทียบวิธี

	การศึกษาความแม่นยำในการวินิจฉัยแบบปรับได้	การทดลองทางคลินิกแบบสุ่มชนิดปรับเปลี่ยนได้
สาขาวิชา	ระบาดวิทยา	ระบาดวิทยา
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	2000s–2010s (adaptive designs codified for diagnostics ~2010s)	Late 1990s–2000s (widespread adoption post-2010)
ผู้ริเริ่ม	Adaptation of STARD framework (Bossuyt et al.) combined with adaptive design principles (Jennison & Turnbull; FDA guidance)	Donald Berry and colleagues; formalized by FDA guidance in 2010 and 2019
ประเภท	Adaptive observational/experimental study design	Experimental clinical trial design
แหล่งต้นตำรับ	Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L., ... & Cohen, J. F. (2015). STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ, 351, h5527.	Berry, D. A. (2006). Bayesian clinical trials. Nature Reviews Drug Discovery, 5(1), 27–36.
ชื่อเรียกอื่น	adaptive DTA study, adaptive diagnostic test evaluation, adaptive test accuracy trial, adaptive STARD study	adaptive RCT, adaptive trial design, response-adaptive randomization trial, adaptive clinical trial
ที่เกี่ยวข้อง	6	6
สรุป	An adaptive diagnostic accuracy study evaluates how well an index test distinguishes between patients with and without a target condition, while incorporating pre-specified interim analyses that allow modifications — such as sample size re-estimation, threshold adjustment, or subgroup enrichment — based on accumulating data. This design improves efficiency and ethical conduct compared to fixed-sample diagnostic studies, particularly when prior prevalence or test performance data are uncertain.	An adaptive randomized clinical trial (adaptive RCT) is a prospective experimental study that uses pre-specified rules to modify one or more trial aspects — such as sample size, allocation ratios, or treatment arms — based on accumulating data collected during the trial itself, while maintaining statistical validity and integrity of the study.