Linganisha mbinu

	Optimization-assisted central composite design	Mbinu ya uso wa mwitikio (RSM)
Nyanja	Muundo wa Majaribio	Muundo wa Majaribio
Familia	Process / pipeline	Hypothesis test
Mwaka wa asili	1951 (CCD); optimization coupling formalized 1970s–1990s	1951
Mwanzilishi	Box & Wilson (CCD, 1951); optimization integration by Myers, Montgomery & colleagues	George E. P. Box & K. B. Wilson
Aina	Experimental design with mathematical optimization	Second-order polynomial response surface model
Chanzo asilia	Myers, R. H., Montgomery, D. C., & Anderson-Cook, C. M. (2009). Response Surface Methodology: Process and Product Optimization Using Designed Experiments (3rd ed.). Wiley. ISBN: 978-0470174463	Box, G. E. P. & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society, Series B, 13(1), 1–45.
Majina mbadala	CCD with optimization, optimized CCD, RSM-CCD optimization, central composite design with response optimization	RSM, Central Composite Design, Box-Behnken Design, CCD
Zinazohusiana	3	7
Muhtasari	Optimization-assisted central composite design (CCD) combines the rotatable, second-order experimental layout of central composite design with mathematical optimization algorithms — typically desirability functions, response surface optimization, or metaheuristics — to find the factor settings that simultaneously maximize, minimize, or hit target values for one or more response variables. It is the most widely applied response-surface optimization workflow in chemical, pharmaceutical, food science, and manufacturing engineering.	Response Surface Methodology is a collection of statistical and mathematical techniques for building an empirical second-order polynomial model that relates a continuous response variable to two or more controllable input factors, and then locating the factor settings that optimize that response. The approach was introduced by George E. P. Box and K. B. Wilson in their landmark 1951 paper and has since become a cornerstone of process optimization across engineering, chemistry, food science, and pharmaceutics.