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| Multicenter Case-Control Study× | Fallstudie× | |
|---|---|---|
| Ämnesområde | Epidemiologi | Epidemiologi |
| Familj | Process / pipeline | Process / pipeline |
| Ursprungsår≠ | Mid-20th century; multicenter framework formalised 1970s–1980s | 1950s (formal methodology); precursors in the 1920s |
| Upphovsperson≠ | Epidemiology convention; seminal statistical framework by Breslow & Day (IARC, 1980) | Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s |
| Typ≠ | Observational analytical epidemiological design | Observational analytic study design |
| Ursprungskälla≠ | Breslow, N. E., & Day, N. E. (1980). Statistical Methods in Cancer Research. Volume I: The Analysis of Case-Control Studies. IARC Scientific Publications No. 32. International Agency for Research on Cancer, Lyon. ISBN: 978-9283211327 | Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860 |
| Alias | multisite case-control study, collaborative case-control study, pooled case-control study, multi-institutional case-control study | case-referent study, case-control design, retrospective case-control, case-control analysis |
| Närliggande | 6 | 6 |
| Sammanfattning≠ | A multicenter case-control study is an observational design that identifies individuals who have developed a disease (cases) and disease-free comparators (controls) across two or more study sites simultaneously. By pooling recruitment across hospitals, clinics, or geographic regions, the design achieves larger sample sizes, captures exposure variability over broader populations, and improves the statistical power needed to detect modest odds ratios for rare or heterogeneous diseases. | A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses. |
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