Uporedite metode

	Meta-analiza zasnovana na meta-regresiji	Mrežna meta-analiza
Oblast	Naukometrija	Sinteza dokaza
Porodica	Process / pipeline	Process / pipeline
Godina nastanka	1993–1999	2002
Tvorac	Stephen G. Thompson & Simon J. Sharp (systematic framework); earlier work by Berlin, Longnecker & Greenland (1993)	Lumley (2002)
Tip	Quantitative evidence synthesis with covariate modeling	Method
Temeljni izvor	Thompson, S. G., & Sharp, S. J. (1999). Explaining heterogeneity in meta-analysis: a comparison of methods. Statistics in Medicine, 18(20), 2693–2708.	Lumley, T. (2002). Network meta-analysis for indirect treatment comparisons. Statistics in Medicine, 21(16), 2313–2324.
Drugi nazivi	meta-regression, meta-analytic regression, weighted regression meta-analysis, MR-MA	Mixed Treatment Comparison, MTC, Indirect Comparison Meta-Analysis
Srodne	4	1
Sažetak	Meta-regression-based meta-analysis extends standard meta-analysis by fitting a weighted regression model in which study-level characteristics (moderators) predict observed effect sizes. Rather than simply pooling effects, this approach asks why effects vary across studies — linking heterogeneity in outcomes to differences in population, intervention, design, or measurement features. It is the primary tool for explaining between-study variance in quantitative evidence synthesis.	Network meta-analysis (NMA) is a systematic method for comparing multiple interventions simultaneously within a single analytical framework, incorporating both direct evidence (head-to-head trials) and indirect evidence (comparisons via common comparators). First formalized by Lumley in 2002, NMA allows researchers to rank treatments and quantify comparative effectiveness even when some treatment pairs have never been directly studied.