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| Izobologramska analiza× | Populaciono farmakodinamičko modelovanje× | |
|---|---|---|
| Oblast | Farmakologija | Farmakologija |
| Porodica | Process / pipeline | Process / pipeline |
| Godina nastanka≠ | 1926 | 1992 |
| Tvorac≠ | Salvatore Loewe | Lewis Sheiner and Stephen Roush |
| Tip≠ | synergy quantification | dose-response modeling |
| Temeljni izvor≠ | Loewe, S. (1926). Die Mischtoxizität. Zeitschrift für Experimentelle Pathologie und Therapie, 24, 315-334. link ↗ | Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57. link ↗ |
| Drugi nazivi | isobol, combination index, synergy testing | PopPD, population PD, hierarchical PD modeling |
| Srodne | 3 | 3 |
| Sažetak≠ | Isobologram analysis is a graphical and quantitative method for detecting and classifying drug interactions, developed by Salvatore Loewe in 1926. It uses dose-response data from two drugs applied individually and in combination to determine whether their interaction is additive, synergistic, or antagonistic. | Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction. |
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