Krahasoni metodat

	Analiza Multi-Omics eQTL	Studimi i Asociacionit të Gjenomit të Gjerë (GWAS)
Fusha	Bioinformatikë	Bioinformatikë
Familja	Process / pipeline	Process / pipeline
Viti i origjinës	2010s–present (foundational eQTL work: ~2007; multi-omics integration: ~2013–2017)	2005–2007
Krijuesi	GTEx Consortium and multi-omics integration pioneers (Nica & Dermitzakis, 2013; GTEx Consortium, 2015–2020)	Klein et al. (age-related macular degeneration GWAS, 2005); landmark scale: Wellcome Trust Case Control Consortium (2007)
Lloji	Integrative genomic association analysis	Observational genomic association study
Burimi themelues	GTEx Consortium. (2017). Genetic effects on gene expression across human tissues. Nature, 550(7675), 204–213.	Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661–678.
Emërtime të tjera	multi-omics molQTL, multi-layer eQTL, integrated eQTL analysis, xQTL multi-omics	GWAS, genome-wide association analysis, whole-genome association study, WGAS
Të lidhura	6	6
Përmbledhja	Multi-omics eQTL analysis maps genetic variants (SNPs or structural variants) to molecular phenotypes simultaneously across multiple omics layers — transcriptome, epigenome, proteome, and metabolome — in the same cohort. By linking genotype to gene expression and then tracing those effects through downstream molecular layers, the approach reveals how genetic variation propagates through the molecular machinery of a cell, yielding mechanistic insight that no single-omics eQTL study can provide.	A genome-wide association study (GWAS) systematically tests hundreds of thousands to millions of single-nucleotide polymorphisms (SNPs) across the human genome for statistical association with a trait or disease. By comparing allele frequencies between cases and controls — or by regressing SNP genotypes on a quantitative phenotype — GWAS identifies genomic loci that harbor common genetic variants contributing to complex traits. Since its large-scale debut in 2007, GWAS has catalogued thousands of robust disease–variant associations across virtually every common human condition.