Differential eQTL Analysis
Differential eQTL analysis identifies genetic variants — expression quantitative trait loci — whose regulatory effect on gene expression varies systematically across biological conditions such as tissue types, disease states, developmental stages, or treatment groups. By testing for statistical interactions between genotype and condition, the method pinpoints loci where the same allele has different transcriptional consequences depending on context, revealing the molecular basis of condition-specific gene regulation.
Zdrojový záznam
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- Stranger, B. E., et al. (2007). Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science, 315(5813), 848–853. · DOI 10.1126/science.1136678
- Huang, Q. Q., et al. (2018). Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications, 9(1), 943. · URL
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