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| Patch-Clamp elektrofyziológia× | Populačné farmakodynamické modelovanie× | |
|---|---|---|
| Odbor | Farmakológia | Farmakológia |
| Rodina | Process / pipeline | Process / pipeline |
| Rok vzniku≠ | 1976 | 1992 |
| Tvorca≠ | Erwin Neher and Bert Sakmann | Lewis Sheiner and Stephen Roush |
| Typ≠ | ion channel screening | dose-response modeling |
| Pôvodný zdroj≠ | Neher, E., & Sakmann, B. (1976). Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature, 260(5554), 799-802. DOI ↗ | Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57. link ↗ |
| Ďalšie názvy | patch clamp, whole-cell recording, ion channel assay | PopPD, population PD, hierarchical PD modeling |
| Príbuzné | 3 | 3 |
| Zhrnutie≠ | Patch-clamp electrophysiology is a technique for measuring ionic currents through ion channels in cell membranes, developed by Neher and Sakmann in 1976. It enables direct observation of single-channel and whole-cell currents at millisecond resolution, making it essential for characterizing drug effects on ion channels and cardiac safety assessment. | Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction. |
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