Porovnať metódy

	Parametric g-Formula	Marginal Structural Model (IPTW)
Odbor	Social Epidemiology	Social Epidemiology
Rodina	Process / pipeline	Process / pipeline
Rok vzniku	1986	2000
Tvorca	James M. Robins; Ashley I. Naimi, Alexander P. Keil et al. (applied tutorial)	James M. Robins, Miguel A. Hernán & Babette Brumback
Typ	Counterfactual simulation pipeline for time-varying treatment regimes	Reweighting pipeline for time-varying confounding affected by prior treatment
Pôvodný zdroj	Robins, J. M. (1986). A new approach to causal inference in mortality studies with a sustained exposure period—application to control of the healthy worker survivor effect. Mathematical Modelling, 7(9-12), 1393-1512.	Robins, J. M., Hernán, M. A., & Brumback, B. (2000). Marginal structural models and causal inference in epidemiology. Epidemiology, 11(5), 550-560.
Ďalšie názvy	g-Computation Formula, Robins' g-Formula, Parametric g-Computation, Generalized Computation Algorithm Formula	MSM with IPTW, Inverse-Probability-of-Treatment-Weighted Marginal Structural Model, IPTW Marginal Structural Model, Robins Marginal Structural Model
Príbuzné	3	3
Zhrnutie	The parametric g-formula is the estimator James Robins introduced in 1986 to recover the causal effect of a time-varying exposure when time-varying confounders are themselves affected by past exposure — a setting where standard regression adjustment is guaranteed to give the wrong answer. Rather than conditioning on the troublesome confounders directly, the g-formula reconstructs the entire counterfactual world: it parametrically estimates how confounders and the outcome evolve over time, then Monte-Carlo simulates what would have happened to the population under a hypothetical exposure regime such as 'always exposed' versus 'never exposed.' Keil and colleagues' 2014 worked tutorial for time-to-event data made the algorithm concrete for epidemiologists. In social epidemiology it is the workhorse for questions like the cumulative effect of sustained neighborhood deprivation, employment, or income trajectories on health, where mediators and confounders are tangled across time.	Marginal structural models, introduced by Robins, Hernán, and Brumback in 2000, are causal models for the mean of a counterfactual outcome under a treatment regime, estimated by inverse-probability-of-treatment weighting. They solve the same problem as the g-formula — estimating the effect of a time-varying exposure when time-varying confounders are themselves affected by prior treatment — but through a different device: instead of modeling the outcome and confounder processes, they reweight each person by the inverse of their probability of receiving the treatment history they actually received. This creates a pseudo-population in which treatment is, by construction, unconfounded by the measured covariates, so a simple weighted regression recovers the causal effect. The companion 2000 paper applying the method to zidovudine and HIV survival showed its practical payoff. In social epidemiology, MSMs with IPTW are standard for the cumulative effects of time-varying social exposures.