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| Adaptívna prípadovo-kontrolná štúdia× | Prípadovo-kontrolná štúdia× | |
|---|---|---|
| Odbor | Epidemiológia | Epidemiológia |
| Rodina | Process / pipeline | Process / pipeline |
| Rok vzniku≠ | 1950s (base design); adaptive extensions developed from the 1970s–1990s | 1950s (formal methodology); precursors in the 1920s |
| Tvorca≠ | Builds on Doll & Hill (1950s) case-control foundations; adaptive elements drawn from sequential analysis (Wald, 1947) and group-sequential methods (Armitage, 1975) | Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s |
| Typ≠ | Adaptive observational epidemiological design | Observational analytic study design |
| Pôvodný zdroj≠ | Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641 | Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860 |
| Ďalšie názvy | adaptive case-control design, sequential case-control study, adaptive observational study, dynamic case-control study | case-referent study, case-control design, retrospective case-control, case-control analysis |
| Príbuzné | 6 | 6 |
| Zhrnutie≠ | An adaptive case-control study is a case-control design that incorporates pre-specified rules allowing modification of study parameters — such as sample size, case-to-control ratio, or matching criteria — based on interim data, without compromising validity. It combines the efficiency of adaptive methodology with the retrospective exposure-ascertainment logic of classical case-control research, enabling investigators to respond to emerging evidence while the study is ongoing. | A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses. |
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