Compară metode
Examinează metodele selectate una lângă alta; rândurile care diferă sunt evidențiate.
| Test de Permeabilitate al Celulelor Caco-2× | Corelație In Vitro-In Vivo× | |
|---|---|---|
| Domeniu | Farmacologie | Farmacologie |
| Familie | Process / pipeline | Process / pipeline |
| Anul apariției≠ | 1989 | 1995 |
| Autorul original≠ | Ingrid Hidalgo | Gordon Amidon |
| Tip≠ | absorption screening | bioavailability prediction |
| Sursa seminală≠ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ | Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413-420. DOI ↗ |
| Denumiri alternative≠ | Caco-2 assay, intestinal permeability, ADME screening | IVIVC |
| Înrudite | 3 | 3 |
| Rezumat≠ | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. | IVIVC is a mathematical relationship between in vitro and in vivo properties of a drug, developed to predict oral bioavailability from dissolution data. Introduced by Amidon and colleagues in the 1995 Biopharmaceutics Classification System, it bridges laboratory measurements and clinical outcomes to streamline drug development. |
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