Comparar métodos

	Modelagem por Homologia	Modelagem de Farmacóforo	Topologia de Rede de Interação Proteína-Proteína
Área	Bioinformática	Bioinformática	Bioinformática
Família	Process / pipeline	Process / pipeline	Process / pipeline
Ano de origem	1993	1977	2000
Autor original	Andrej Sali	Peter Gund	Peter Uetz
Tipo	Comparative structure prediction pipeline	Pattern-based virtual screening pipeline	Network analysis pipeline
Fonte seminal	Sali, A. & Blundell, T. L. (1993). Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology, 234(3), 779-815.	Wermuth, C. G., Ganellin, C. R., Lindberg, P., & Mitscher, L. A. (1998). Glossary of terms used in medicinal chemistry. Pure and Applied Chemistry, 70(5), 1129-1143.	Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., ... & Lomax, J. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403(6770), 623-627.
Outros nomes	comparative modeling, template-based modeling	pharmacophore pattern recognition, 3D pharmacophore	protein interaction networks, interactome analysis, network topology
Relacionados	4	3	3
Resumo	Homology modeling, also called comparative modeling, predicts the three-dimensional structure of a protein using an experimentally-solved structure of a homologous protein as a template. Introduced by Sali and Blundell in 1993, this method exploits the principle that homologous proteins share similar spatial structures despite differing in amino acid sequence.	Pharmacophore modeling identifies the spatial arrangement of molecular features (hydrogen bond donors, acceptors, aromatic rings) that are essential for biological activity. Introduced by Gund in 1977, this ligand-based method creates a three-dimensional pattern that can screen chemical libraries and design new active compounds without requiring receptor structure.	Protein-protein interaction network analysis identifies and characterizes the structural properties of cellular interaction networks. Pioneered by Uetz and colleagues through large-scale yeast two-hybrid screening, this approach reveals topological features like hubs, modules, and motifs that encode functional organization and disease associations.