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COSY×FT-ICR Mass Spectrometry×
ÁreaEspectroscopiaEspectroscopia
FamíliaProcess / pipelineProcess / pipeline
Ano de origem19761974
Autor originalWüthrich KurtAlan Marshall
TipoTwo-dimensional pulse sequenceMass spectrometry technique
Fonte seminalAue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246. DOI ↗Comisarow, M. B., & Marshall, A. G. (1974). Fourier transform ion cyclotron resonance spectroscopy. Chemical Physics Letters, 25(2), 282-283. DOI ↗
Outros nomesCOSY NMR, 2D COSY, 1H-1H COSYFT-ICR-MS, Fourier Transform ICR, ICR mass spectrometry
Relacionados44
ResumoCorrelation Spectroscopy (COSY) is a two-dimensional NMR technique that correlates proton chemical shifts through scalar coupling (J-coupling), revealing which protons are magnetically coupled and hence bonded through multiple bonds. Developed by Aue, Bartholdi, and Ernst in 1976, COSY became one of the most important tools in structural elucidation, enabling chemists to map out proton connectivity patterns and deduce molecular topology without isotopic labeling.Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry is an advanced analytical technique that combines magnetic confinement of ions with Fourier transform data processing to achieve exceptional mass accuracy and resolution. Developed by Comisarow and Marshall in 1974, FT-ICR-MS enables the determination of exact masses and elemental compositions of complex molecules, making it invaluable for environmental chemistry, metabolomics, petroleum characterization, and structural elucidation of unknowns.
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ScholarGateComparar métodos: COSY · FT-ICR Mass Spectrometry. Recuperado em 2026-06-20 de https://scholargate.app/pt/compare