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| Analiza zmienności liczby kopii w pojedynczych komórkach× | Single-cell GWAS× | |
|---|---|---|
| Dziedzina | Bioinformatyka | Bioinformatyka |
| Rodzina | Process / pipeline | Process / pipeline |
| Rok powstania≠ | 2011–2015 | 2019–2022 (rapid emergence with large-scale scRNA-seq atlases) |
| Twórca≠ | Navin et al. (single-cell sequencing for CNV); Garvin et al. (Ginkgo tool, 2015) | Multiple groups (Price lab, De Jager lab, others); scDRS framework by Zhang et al. 2022 |
| Typ≠ | Computational genomics pipeline | Integrative genomic analysis pipeline |
| Źródło pierwotne≠ | Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G. S., Hicks, J., Wigler, M., & Schatz, M. C. (2015). Interactive analysis and assessment of single-cell copy-number variations. Nature Methods, 12(11), 1058–1060. link ↗ | Zhang, M. J., Hou, K., Dey, K. K., Sakaue, S., Jagadeesh, K. A., Weinand, K., ... & Price, A. L. (2022). Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data. Nature Genetics, 54(8), 1224-1234. link ↗ |
| Inne nazwy | scCNV analysis, single-cell CNV, scCNA analysis, single-cell copy number aberration analysis | sc-GWAS, single-cell GWAS integration, cell-type-specific GWAS, single-cell genetic association analysis |
| Pokrewne | 6 | 6 |
| Podsumowanie≠ | Single-cell copy number variation (scCNV) analysis detects gains and losses of genomic segments within individual cells, enabling researchers to resolve intratumor heterogeneity, reconstruct clonal evolution, and distinguish malignant from normal cells at single-cell resolution. It can be applied to single-cell whole-genome sequencing data directly or inferred from read-depth signals in scRNA-seq or scATAC-seq experiments. | Single-cell GWAS is an integrative bioinformatics pipeline that maps genome-wide association study (GWAS) signals onto single-cell transcriptomic landscapes to identify which cell types and individual cells carry disproportionate genetic risk for a disease or trait. By leveraging single-cell RNA-seq atlases alongside GWAS summary statistics, it moves beyond tissue-level associations to reveal the precise cellular contexts in which disease-associated genetic variants exert their effects. |
| ScholarGateZbiór danych ↗ |
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