Bayesian Microbiome Diversity Analysis
Bayesian microbiome diversity analysis applies probabilistic models — chiefly Dirichlet-Multinomial and related hierarchical frameworks — to 16S rRNA or shotgun metagenomic count data to estimate alpha-diversity (within-sample richness and evenness) and beta-diversity (between-sample compositional differences) while propagating uncertainty through the entire inference chain. Unlike frequentist rarefaction-based approaches, Bayesian methods treat taxon counts as draws from a latent composition, enabling credible intervals on diversity metrics and principled comparison across groups with unequal sequencing depth.
Kilderegister
Siteringer kopiert ordrett fra metodens kilderegister. Ingen påstandsnivåverifisering er underforstått fra dem.
- Holmes, I., Harris, K., & Quince, C. (2012). Dirichlet Multinomial Mixtures: Generative Models for Microbial Metagenomics. PLOS ONE, 7(2), e30126. · URL
- La Rosa, P. S., Brooks, J. P., Deych, E., Boone, E. L., Edwards, D. J., Wang, Q., Sodergren, E., Weinstock, G., & Shannon, W. D. (2012). Hypothesis Testing and Power Calculations for Taxonomic-Based Human Microbiome Data. PLOS ONE, 7(12), e52078. · URL
Kuraterte påstander
Påstander lagret i bevishovedboken, hver med sin egen vurdering.
Denne visningen finner ikke opp en påstandsvurdering når hovedboken ikke har noen.
Relaterte metoder
Generert fra metodegrafen og vist som maskinforslåtte relasjoner – ingen bevispåstand er underforstått.