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Risico-gecorrigeerde diagnostische nauwkeurigheidsstudie×Studieontwerp voor diagnostische nauwkeurigheid×
VakgebiedEpidemiologieKlinisch onderzoek
FamilieProcess / pipelineProcess / pipeline
Jaar van ontstaanConceptual roots 1980s–1990s; covariate-adjusted ROC formally introduced 20092003-2015
GrondleggerMargaret Pepe and colleagues; covariate-adjusted ROC formalized by Janes & Pepe (2009)Bossuyt, Reitsma, and STARD group (2003); clinical epidemiology pioneers
TypeObservational clinical study design with covariate adjustmentResearch Design
Oorspronkelijke bronPepe, M. S. (2003). The Statistical Evaluation of Medical Tests for Classification and Prediction. Oxford University Press. ISBN: 978-0198509844Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., ... & de Vet, H. C. (2003). Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Annals of Internal Medicine, 138(1), 40–44. DOI ↗
Aliassencase-mix-adjusted diagnostic accuracy, stratified diagnostic accuracy study, covariate-adjusted diagnostic accuracy, risk-stratified DTA studydiagnostic accuracy study, test accuracy, STARD, diagnostic evaluation
Verwant62
SamenvattingA risk-adjusted diagnostic accuracy study evaluates how well an index test identifies a target condition while explicitly accounting for patient-level risk factors that influence either disease prevalence or test performance. By adjusting for case-mix, it yields accuracy estimates — sensitivity, specificity, and AUC — that are not confounded by the composition of the study sample, enabling fairer comparisons across populations and clinical settings.A diagnostic accuracy study evaluates how well a new diagnostic test (or biomarker, imaging modality, clinical assessment) detects the presence or absence of disease compared to a reference standard (gold standard). Standardized since 2003 by the STARD (Standards for Reporting of Diagnostic Accuracy Studies) initiative, diagnostic accuracy studies are fundamental to clinical medicine, determining whether and how new tests can improve patient diagnosis and treatment.
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ScholarGateMethoden vergelijken: Risk-adjusted diagnostic accuracy study · Diagnostic Accuracy Study Design. Geraadpleegd op 2026-06-18 via https://scholargate.app/nl/compare