Methoden vergelijken

	Nelson-Aalen Cumulatieve Hazard Schatter	Cox Proportionele Risico's Regressie	Shared Frailty Model voor Geklusterde Overlevingsdata	Log-rang-test voor het vergelijken van overlevingscurven
Vakgebied	Overlevingsanalyse	Overlevingsanalyse	Overlevingsanalyse	Overlevingsanalyse
Familie	Survival analysis	Survival analysis	Survival analysis	Survival analysis
Jaar van ontstaan	1972	1972	1979	1966
Grondlegger	Wayne Nelson & Odd Aalen	Cox, D. R.	Vaupel, J.W., Manton, K.G. & Stallard, E.	Mantel, N.
Type	Non-parametric cumulative hazard estimator	Semi-parametric hazard regression model	Random effects survival model	Non-parametric hypothesis test
Oorspronkelijke bron	Nelson, W. (1972). Theory and applications of hazard plotting for censored failure data. Technometrics, 14(4), 945–966.	Cox, D. R. (1972). Regression Models and Life-Tables. Journal of the Royal Statistical Society: Series B, 34(2), 187–202.	Vaupel, J.W., Manton, K.G. & Stallard, E. (1979). The Impact of Heterogeneity in Individual Frailty on the Dynamics of Mortality. Demography, 16(3), 439–454.	Mantel, N. (1966). Evaluation of Survival Data and Two New Rank Order Statistics Arising in Its Consideration. Cancer Chemotherapy Reports, 50(3), 163–170.
Aliassen	Nelson-Aalen cumulative hazard, Aalen estimator, empirical cumulative hazard, Nelson-Aalen kümülatif hazard tahmincisi	cox ph model, proportional hazards model, cox ph regression, Cox Orantılı Tehlikeler Regresyonu	shared frailty model, random effects survival model, Frailty Modeli (Paylaşılan Kırılganlık)	Mantel log-rank test, Mantel-Cox test, log-rank sağkalım testi, Log-Rank Testi
Verwant	5	3	3	2
Samenvatting	The Nelson-Aalen estimator is a non-parametric estimator of the cumulative hazard function from right-censored time-to-event data. Developed by Wayne Nelson for reliability hazard plotting in 1972 and placed on a rigorous counting-process foundation by Odd Aalen in 1978, it accumulates the ratio of observed events to the number at risk at each event time, providing the natural hazard-scale companion to the Kaplan-Meier survival curve.	Cox proportional hazards regression, introduced by D. R. Cox in 1972, is a semi-parametric model that estimates how one or more covariates affect the hazard — the instantaneous rate of experiencing an event — while leaving the baseline hazard function unspecified. It is the standard multivariable method in survival analysis and produces hazard ratios that quantify the relative risk associated with each predictor.	The shared frailty model, introduced by Vaupel, Manton, and Stallard in 1979, extends standard survival regression by incorporating a random effect — the 'frailty' — that captures unobserved heterogeneity among subjects or clusters. When survival outcomes are measured on individuals who share a common environment (patients in the same hospital, members of the same family, animals in the same litter), a frailty term accounts for the within-cluster dependence that ordinary Cox regression ignores.	The log-rank test, developed by Nathan Mantel in 1966, is a non-parametric hypothesis test that compares the overall survival experience of two or more groups throughout the entire follow-up period. It is the standard companion to Kaplan-Meier curves and determines whether observed differences between curves are statistically meaningful.