Methoden vergelijken

	Multicenter Cox Proportionele Gevaren	Cox Proportional Hazards
Vakgebied	Epidemiologie	Epidemiologie
Familie	Process / pipeline	Process / pipeline
Jaar van ontstaan	1972 (Cox model); multicenter applications formalized 1980s–1990s	1972
Grondlegger	D. R. Cox (Cox PH model); multicenter extension developed through collaborative trial methodology	Sir David Roxbee Cox
Type	Semi-parametric survival regression for clustered data	Semi-parametric regression model
Oorspronkelijke bron	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
Aliassen	multicenter Cox regression, multisite Cox PH model, stratified Cox model across centers, multicenter survival regression	Cox regression, Cox PH model, proportional hazards model, CPH
Verwant	4	5
Samenvatting	Multicenter Cox proportional hazards regression extends the classic Cox PH model to studies conducted at two or more clinical sites or centers. It estimates the effect of predictors on time-to-event outcomes while explicitly accounting for clustering within centers, between-center heterogeneity, and potential differences in baseline hazard across sites. This design is standard practice in large multicenter RCTs and observational cohort studies in oncology, cardiology, and other clinical fields.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.