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Matched dose-response analysis×Dosis-responsanalyse×
VakgebiedEpidemiologieEpidemiologie
FamilieProcess / pipelineProcess / pipeline
Jaar van ontstaan1970s–1980sConceptual roots 16th century; modern epidemiological application mid-20th century
GrondleggerDeveloped within the matched case-control framework; formalized by Breslow and Day (1980) and Rothman and colleaguesParacelsus (conceptual foundation); formalized by John Snow and later Bradford Hill
TypeAnalytical epidemiological methodQuantitative analytical method
Oorspronkelijke bronRothman, K.J., Greenland, S., & Lash, T.L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
Aliassenmatched trend analysis, dose-response in matched designs, exposure-response analysis with matching, matched exposure-gradient analysisexposure-response analysis, concentration-response modeling, dose-response modeling, DRA
Verwant44
SamenvattingMatched dose-response analysis evaluates whether increasing levels of exposure are associated with proportionally increasing (or decreasing) risk of an outcome, within a study where cases and controls — or exposed and unexposed individuals — have been deliberately matched on key confounders such as age, sex, or study site. Matching controls residual confounding structurally, while the dose-response component tests whether the exposure-outcome relationship follows a biologically plausible gradient, strengthening causal inference.Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.
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ScholarGateMethoden vergelijken: Matched dose-response analysis · Dose-Response Analysis. Geraadpleegd op 2026-06-17 via https://scholargate.app/nl/compare