Methoden vergelijken

	ML-ondersteunde Epigenoombrede Associatiestudie (ML-EWAS)	Lasso-regressie
Vakgebied	Bio-informatica	Machine learning
Familie	Process / pipeline	Machine learning
Jaar van ontstaan	2010s (methodological consolidation ~2015–2020)	1996
Grondlegger	Teschendorff, Relton, and others in the epigenomics field	Tibshirani, R.
Type	Integrative omics analysis pipeline	Regularized linear regression (L1 penalty)
Oorspronkelijke bron	Teschendorff, A. E., & Relton, C. L. (2018). Statistical and integrative system-level analysis of DNA methylation data. Nature Reviews Genetics, 19(3), 129–147.	Tibshirani, R. (1996). Regression Shrinkage and Selection via the Lasso. Journal of the Royal Statistical Society: Series B, 58(1), 267–288.
Aliassen	ML-EWAS, machine learning EWAS, ML-assisted EWAS, epigenome-wide association study with machine learning	LASSO Regresyonu, lasso, L1-regularized regression, L1 regularization
Verwant	3	4
Samenvatting	Machine learning-assisted EWAS integrates conventional epigenome-wide association testing with machine learning models to identify DNA methylation sites associated with a phenotype of interest. By combining the statistical rigour of EWAS with the pattern-recognition power of algorithms such as elastic net, random forest, or gradient boosting, this approach handles the extreme dimensionality of methylation arrays (450,000–850,000 CpG sites) more effectively than univariate testing alone, and can capture non-linear and interaction effects that standard linear models miss.	Lasso regression, introduced by Robert Tibshirani in 1996, is a linear regression method that adds an L1 penalty to the loss so that it shrinks coefficients and performs variable selection at the same time, producing a sparse model. By driving some coefficients exactly to zero it keeps only the predictors that matter.