Methoden vergelijken

	Genoombrede associatiestudie (GWAS)	Mediatiemanalyse
Vakgebied	Bio-informatica	Statistiek
Familie	Process / pipeline	Hypothesis test
Jaar van ontstaan	2005–2007	1986
Grondlegger	Klein et al. (age-related macular degeneration GWAS, 2005); landmark scale: Wellcome Trust Case Control Consortium (2007)	Baron & Kenny
Type	Observational genomic association study	Indirect effects / path test
Oorspronkelijke bron	Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661–678.	Baron, R. M. & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research. Journal of Personality and Social Psychology, 51(6), 1173–1182.
Aliassen	GWAS, genome-wide association analysis, whole-genome association study, WGAS	indirect effects analysis, path-based mediation, PROCESS macro mediation, Aracılık Analizi (Mediation / PROCESS)
Verwant	6	5
Samenvatting	A genome-wide association study (GWAS) systematically tests hundreds of thousands to millions of single-nucleotide polymorphisms (SNPs) across the human genome for statistical association with a trait or disease. By comparing allele frequencies between cases and controls — or by regressing SNP genotypes on a quantitative phenotype — GWAS identifies genomic loci that harbor common genetic variants contributing to complex traits. Since its large-scale debut in 2007, GWAS has catalogued thousands of robust disease–variant associations across virtually every common human condition.	Mediation analysis is a statistical procedure that tests whether the effect of an independent variable X on an outcome Y operates wholly or partly through a third variable M, called the mediator. Formalised by Baron and Kenny in 1986, it decomposes the total effect of X on Y into a direct path (c′) and an indirect path (a × b), quantifying how much of the relationship is carried by the mediating mechanism.