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Rekristalizācija×Kolonnas hromatogrāfija×Plānošana sintēzes maršrutu×Plānslāņa hromatogrāfija×
NozareĶīmijaĶīmijaĶīmijaĶīmija
SaimeProcess / pipelineProcess / pipelineProcess / pipelineProcess / pipeline
Izcelsmes gadsearly 19th century190319691956
AutorsOrganic chemistry traditionMikhail TsvetElias James CoreyEgon Stahl
TipsPurification techniqueChromatographic separation techniqueStrategic planning methodologyChromatographic separation technique
PirmavotsPavia, D. L., Lampman, G. M., Kriz, G. S., & Engel, R. G. (2014). A Small-Scale Approach to Organic Laboratory Techniques (4th ed.). Cengage Learning. ISBN: 978-1285749297Skoog, D. A., Holler, F. J., & Crouch, S. R. (2017). Principles of Instrumental Analysis (7th ed.). Cengage Learning. ISBN: 978-1305577213Corey, E. J., & Cheng, X. M. (1991). The Logic of Chemical Synthesis. John Wiley & Sons. ISBN: 978-0471096092Sherma, J. (2003). Planar Chromatography. Analytical Chemistry, 75(12), 2783–2811. DOI ↗
Citi nosaukumicrystallization purification, recrystallisationliquid chromatography, column liquid chromatographyretrosynthesis, retrosynthetic analysis, synthetic route designTLC, planar chromatography
Saistītās3333
KopsavilkumsRecrystallization is a classical purification technique in which a solid compound is dissolved in hot solvent, then allowed to crystallize upon cooling, yielding pure crystals while impurities remain in solution. Practiced for centuries in chemistry laboratories, recrystallization remains one of the most effective and accessible methods for purifying organic solids, especially when the target compound has low solubility at low temperatures.Column chromatography is a liquid separation technique in which a stationary phase (typically silica gel or alumina) is packed into a vertical column, and a mobile phase (solvent) percolates through it to separate mixture components. Pioneered by Mikhail Tsvet in 1903, column chromatography remains the workhorse of organic chemistry laboratories for purifying reaction products and isolating target compounds.Synthesis route planning, grounded in retrosynthetic analysis, is a strategic approach to designing efficient chemical syntheses. Formalized by Elias James Corey in the 1960s (earning him the Nobel Prize in 1990), this methodology systematically deconstructs target molecules into simpler precursors and starting materials, enabling chemists to discover logical, economical, and practical synthesis routes.Thin-Layer Chromatography (TLC) is a planar chromatographic technique that separates compounds based on their differential affinities for a mobile and stationary phase. Developed by Egon Stahl in 1956, TLC remains one of the most accessible and widely used analytical methods in organic and inorganic chemistry, laboratories, and quality control.
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ScholarGateSalīdzināt metodes: Recrystallization · Column Chromatography · Synthesis Route Planning · Thin-Layer Chromatography. Izgūts 2026-06-18 no https://scholargate.app/lv/compare