手法を比較

	前向き用量反応分析	用量反応分析
分野	疫学	疫学
系統	Process / pipeline	Process / pipeline
提唱年	1965 (Hill's criteria); widely applied through 1980s–present	Conceptual roots 16th century; modern epidemiological application mid-20th century
提唱者	Bradford Hill (causal criteria including dose-response, 1965); formalized in modern epidemiology by Rothman, Greenland and others	Paracelsus (conceptual foundation); formalized by John Snow and later Bradford Hill
種類	Analytical epidemiological study design	Quantitative analytical method
原典	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
別名	prospective exposure-response analysis, prospective trend analysis, forward-looking dose-response study, prospective gradient analysis	exposure-response analysis, concentration-response modeling, dose-response modeling, DRA
関連	4	4
概要	Prospective dose-response analysis is an epidemiological approach that measures exposure levels in a defined population before outcomes occur, then quantifies how the risk or magnitude of an outcome changes systematically as exposure increases. By collecting exposure data prospectively, researchers can establish temporal sequence, reduce recall bias, and assess whether a biological gradient — one of Hill's classic causal criteria — exists between the agent of interest and a health outcome.	Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.