手法を比較

	ファーマコビジランスにおけるPRR/ROR	Caco-2細胞透過性アッセイ
分野	薬理学	薬理学
系統	Process / pipeline	Process / pipeline
提唱年	2002	1989
提唱者	Arne Melander and colleagues	Ingrid Hidalgo
種類	safety signal detection	absorption screening
原典	Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631.	Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749.
別名	PRR, ROR, signal detection, adverse event monitoring	Caco-2 assay, intestinal permeability, ADME screening
関連	3	3
概要	Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation.	The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport.