手法を比較

	多施設共同コホート研究	ネステッドケースコントロール研究
分野	疫学	疫学
系統	Process / pipeline	Process / pipeline
提唱年	Mid-to-late 20th century (widespread adoption 1970s–1990s)	1973–1977
提唱者	Developed incrementally through large collaborative epidemiological projects (e.g., Framingham Heart Study consortium expansions, 1948 onward; EPIC study, 1992)	Nathan Mantel (1973); D. C. Thomas (1977 formalization)
種類	Observational longitudinal study	Hybrid observational study design
原典	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491.
別名	multisite cohort study, multi-centre cohort, collaborative cohort study, pooled cohort study	NCC study, nested CC design, case-control within cohort, density sampling case-control
関連	6	6
概要	A multicenter cohort study follows defined groups of participants at two or more geographically or institutionally distinct sites over time to estimate incidence, identify risk factors, and quantify associations between exposures and outcomes. By pooling data from multiple centers, it achieves statistical power and population diversity that single-site designs cannot match, making it the workhorse of large-scale epidemiological and clinical research.	A nested case-control study is an efficient observational design embedded within a defined cohort. For each participant who develops the outcome of interest (a case), a small number of matched controls are sampled from those still at risk at the same point in time. This density-sampling strategy yields odds ratios that approximate incidence-rate ratios from the full cohort at a fraction of the data-collection cost — making it the preferred alternative when measuring exposures for all cohort members would be prohibitively expensive or technically demanding.