手法を比較

	磁化移動比	拡散 커토시스 イメージング (Diffusion Kurtosis Imaging, DKI)
分野	神経画像学	神経画像学
系統	Process / pipeline	Process / pipeline
提唱年	1989	2005
提唱者	Stephen Wolff	Jens Jensen
種類	Tissue microstructure characterization	Microstructural white matter analysis
原典	Wolff, S. D., & Balaban, R. S. (1989). Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Journal of Magnetic Resonance Imaging, 10(2), 135–148.	Jensen, J. H., Helpern, J. A., Ramani, A., et al. (2005). Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by magnetic resonance imaging. Magnetic Resonance in Medicine, 53(6), 1432–1440.
別名	MTR, magnetization transfer, MT imaging	DKI, non-Gaussian diffusion, diffusion kurtosis
関連	3	3
概要	Magnetisation Transfer Ratio (MTR) is an MRI method that measures the exchange of magnetization between free water protons and protons bound to macromolecules (primarily myelin lipids and proteins). Introduced by Wolff and Balaban in 1989, MTR reflects tissue macromolecular content and is particularly sensitive to myelination, providing a non-invasive estimate of myelin density.	Diffusion Kurtosis Imaging (DKI) is an advanced diffusion MRI technique that quantifies non-Gaussian diffusion of water molecules, providing detailed information about tissue microstructure beyond conventional diffusion tensor imaging. Introduced by Jensen and colleagues in 2005, DKI detects deviations from normal Gaussian diffusion, revealing information about cellular compartmentalization and fiber heterogeneity.