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| イソボログラム解析× | Chou-Talalay法× | |
|---|---|---|
| 分野 | 薬理学 | 薬理学 |
| 系統 | Process / pipeline | Process / pipeline |
| 提唱年≠ | 1926 | 1983 |
| 提唱者≠ | Salvatore Loewe | Ting-Chao Chou and Paul Talalay |
| 種類 | synergy quantification | synergy quantification |
| 原典≠ | Loewe, S. (1926). Die Mischtoxizität. Zeitschrift für Experimentelle Pathologie und Therapie, 24, 315-334. link ↗ | Chou, T. C., & Talalay, P. (1983). Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Advances in Enzyme Regulation, 22, 27-55. DOI ↗ |
| 別名 | isobol, combination index, synergy testing | CI method, Chou method, median-effect analysis |
| 関連 | 3 | 3 |
| 概要≠ | Isobologram analysis is a graphical and quantitative method for detecting and classifying drug interactions, developed by Salvatore Loewe in 1926. It uses dose-response data from two drugs applied individually and in combination to determine whether their interaction is additive, synergistic, or antagonistic. | The Chou-Talalay method is a quantitative framework for analyzing drug interactions, developed by Ting-Chao Chou and Paul Talalay in 1983. It combines median-effect principle with the combination index (CI) to provide rigorous, model-independent assessment of synergistic, additive, or antagonistic drug effects. |
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