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	HSQC	NMRスピンエコー
分野	分光学	分光学
系統	Process / pipeline	Process / pipeline
提唱年	1980	1950
提唱者	Anil Kumar	Erwin Hahn
種類	Heteronuclear correlation sequence	Spectroscopic pulse sequence
原典	Bodenhausen, G., & Ruben, D. J. (1981). Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy. Chemical Physics Letters, 69(2), 185-189.	Hahn, E. L. (1950). Spin echoes. Physical Review, 80(4), 580-594.
別名	HSQC NMR, 1H-13C HSQC, heteronuclear correlation	CPMG pulse sequence, spin-echo NMR
関連	4	4
概要	Heteronuclear Single-Quantum Coherence (HSQC) is a 2D NMR technique that correlates proton and carbon-13 (or other heteronuclei) chemical shifts through one-bond coupling constants (1JHX). Developed in the early 1980s, HSQC rapidly became the workhorse of structural chemistry because it directly maps which carbons bear which protons, providing a comprehensive view of carbon skeleton connectivity and substitution patterns.	The spin-echo is a fundamental nuclear magnetic resonance (NMR) pulse sequence technique introduced by Erwin Hahn in 1950. It uses a 90-degree radiofrequency pulse followed by a 180-degree refocusing pulse to create an echo, effectively reversing the effects of magnetic field inhomogeneities and allowing accurate measurement of spin relaxation properties. This technique is essential in modern NMR spectroscopy for both one-dimensional and multidimensional experiments.